All Phenotypes Kdm6a<tm1.1Kaig> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdm6a^tm1.1Kaig
targeted mutation 1.1, Kai Ge
MGI:5448754

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm6a^tm1.1Kaig/Kdm6a^tm1.1Kaig	involves: 129S4/SvJaeSor	MGI:5448829
cn2	Kdm6a^tm1.1Kaig/Kdm6a^tm1.1Kaig Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5779968
cn3	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5779969
cn4	Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5779970
ot5	Kdm6a^tm1.1Kaig/Y	involves: 129S4/SvJaeSor	MGI:5488641

Allelic Composition	Kdm6a^tm1.1Kaig/Kdm6a^tm1.1Kaig
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^tm1.1Kaig mutation (1 available); any Kdm6a mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:190157 )

• mice are indistinguishable from wild-type mice

Allelic Composition	Kdm6a^tm1.1Kaig/Kdm6a^tm1.1Kaig Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^tm1.1Kaig mutation (1 available); any Kdm6a mutation (38 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:232700 )

• muscle progenitor cells fail to differentiate ex vitro

impaired skeletal muscle regeneration ( J:232700 )

• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice

• however, mice exhibit regeneration of smaller caliber myofibers

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (942 available)
Kdm6a^tm1.1Kaig mutation (1 available); any Kdm6a mutation (38 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

impaired skeletal muscle regeneration ( J:232700 )

• in tamoxifen-treated mice following CTX-induced muscle injury

Allelic Composition	Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:232700 )

• muscle progenitor cells fail to differentiate ex vitro

impaired skeletal muscle regeneration ( J:232700 )

• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice

• however, mice exhibit regeneration of smaller caliber myofibers

Allelic Composition	Kdm6a^tm1.1Kaig/Y
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^tm1.1Kaig mutation (1 available); any Kdm6a mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:190157 )

• mice are indistinguishable from wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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