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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irx6tm1Chow
targeted mutation 1, Robert L Chow
MGI:5448232
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irx6tm1Chow/Irx6tm1Chow involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ MGI:5448237
cx2
 		Irx6tm1Chow/Irx6tm1Chow
Vsx1tm1Mci/Vsx1tm1Mci 		involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ MGI:5448239


Genotype
MGI:5448237
hm1
Allelic
Composition		 Irx6tm1Chow/Irx6tm1Chow
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx6tm1Chow mutation (0 available); any Irx6 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina bipolar cell morphology ( J:189955 )
• expression analysis indicates defects in type 2 and type 3a bipolar cells and a mixed subtype identity in Hcn4 expressing OFF bipolar cells
• expansion of Hcn4 expression OFF bipolar cells into the entire OFF region (sublamina 1 and 2) of the inner plexiform layer
abnormal retina inner plexiform layer morphology ( J:189955 )
• expansion of Hcn4 expression OFF bipolar cells into the entire OFF region (sublamina 1 and 2) of the inner plexiform layer
abnormal cone electrophysiology ( J:189955 )
• decrease in light adapted a wave amplitude
• however, light adapted OFF visual signaling responses are intact
abnormal rod electrophysiology ( J:189955 )
• decrease in dark adapted a and b wave amplitude

nervous system
abnormal retina bipolar cell morphology ( J:189955 )
• expression analysis indicates defects in type 2 and type 3a bipolar cells and a mixed subtype identity in Hcn4 expressing OFF bipolar cells
• expansion of Hcn4 expression OFF bipolar cells into the entire OFF region (sublamina 1 and 2) of the inner plexiform layer




Genotype
MGI:5448239
cx2
Allelic
Composition		 Irx6tm1Chow/Irx6tm1Chow
Vsx1tm1Mci/Vsx1tm1Mci
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx6tm1Chow mutation (0 available); any Irx6 mutation (27 available)
Vsx1tm1Mci mutation (0 available); any Vsx1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina bipolar cell morphology ( J:189955 )
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls

nervous system
abnormal retina bipolar cell morphology ( J:189955 )
• all Hcn4 expressing cells also express Tacr3, unlike in wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory