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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli
targeted mutation 1, Ming O Li
MGI:5447989
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Foxo1tm1Flv/Foxo1tm1Flv
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+ 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:5448151
cn2
 		Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5448149


Genotype
MGI:5448151
cn1
Allelic
Composition		 Foxo1tm1Flv/Foxo1tm1Flv
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Flv mutation (3 available); any Foxo1 mutation (34 available)
Foxp3tm4(YFP/icre)Ayr mutation (3 available); any Foxp3 mutation (57 available)
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:189962 )
N
• the lethal inflammatory phenotype is completely rescued

immune system
immune system phenotype ( J:189962 )
N
• the lethal inflammatory phenotype is completely rescued




Genotype
MGI:5448149
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (3 available); any Foxp3 mutation (57 available)
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:189962 )
N
• mice exhibit normal regulatory T cell differentiation and homeostasis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory