About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chit1tm1Eli
targeted mutation 1, Jack A Elias
MGI:5447948
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chit1tm1Eli/Chit1tm1Eli involves: C57BL/6 MGI:5447951
cx2
 		Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli/0 		involves: C57BL/6 MGI:5447952
cx3
 		Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-Il13)2Eli/0 		involves: C57BL/6 * CBA MGI:5447953


Genotype
MGI:5447951
hm1
Allelic
Composition		 Chit1tm1Eli/Chit1tm1Eli
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation (0 available); any Chit1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:189872 )
• bleomycin-treated mice exhibit reduced pulmonary fibrosis compared with control mice
• however, bleomycin-induced inflammation is normal




Genotype
MGI:5447952
cx2
Allelic
Composition		 Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation (0 available); any Chit1 mutation (32 available)
Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:189872 )
• doxycycline-treated mice exhibit exacerbated bleomycin-induced pulmonary fibrosis compared with Tg(Scgb1a1-rtTA,tetO-CHIT1)#Eli mice
• however, bleomycin-induced inflammation is normal




Genotype
MGI:5447953
cx3
Allelic
Composition		 Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-Il13)2Eli/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation (0 available); any Chit1 mutation (32 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:189872 )
• bleomycin-treated mice exhibit reduced pulmonary fibrosis and inflammation compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory