Phenotypes associated with this allele

• Allele Symbol: Nras^tm1.1Emfu
• Allele Name: targeted mutation 1.1, Ernst-Martin Fuchtbauer
• Allele ID: MGI:5447943
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nras^tm1.1Emfu/Nras^tm1.1Emfu	involves: 129S1/Sv * FVB/N	MGI:5447944
ht2	Nras^tm1.1Emfu/Nras^+	involves: 129S1/Sv * FVB/N	MGI:5447946

Genotype
MGI:5447944

hm1

• Allelic Composition: Nras^tm1.1Emfu/Nras^tm1.1Emfu
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:189834 )

• born at the expected ratio but die before weaning

growth/size/body

weight loss ( J:189834 )

• progressively lose weight after 1 week of age

postnatal growth retardation ( J:189834 )

• after 1 week of age

immune system

abnormal granulocyte differentiation ( J:189834 )

• full development into granulocytes appears to be interrupted or delayed in the spleen

abnormal thymus morphology ( J:189834 )

• increase in cells in region 1 mainly due to an increase in Gr-1^dim CD11b+ cells

abnormal leukocyte cell number ( J:189834 )

increased granulocyte number ( J:189834 )

• in the spleen and blood of young mice

increased T cell number ( J:189834 )

• increase in the number of CD3+ T cells in the spleen

• mice that are more severely affected by weight loss show greater increases in CD3+ T cells

decreased monocyte cell number ( J:189834 )

• in the spleen of young mice

decreased spleen weight ( J:189834 )

liver/biliary system

pale liver ( J:189834 )

• very pale

hematopoietic system

abnormal granulocyte differentiation ( J:189834 )

• full development into granulocytes appears to be interrupted or delayed in the spleen

abnormal thymus morphology ( J:189834 )

• increase in cells in region 1 mainly due to an increase in Gr-1^dim CD11b+ cells

abnormal leukocyte cell number ( J:189834 )

increased granulocyte number ( J:189834 )

• in the spleen and blood of young mice

increased T cell number ( J:189834 )

• increase in the number of CD3+ T cells in the spleen

• mice that are more severely affected by weight loss show greater increases in CD3+ T cells

decreased monocyte cell number ( J:189834 )

• in the spleen of young mice

decreased spleen weight ( J:189834 )

cellular

abnormal granulocyte differentiation ( J:189834 )

• full development into granulocytes appears to be interrupted or delayed in the spleen

endocrine/exocrine glands

abnormal thymus morphology ( J:189834 )

• increase in cells in region 1 mainly due to an increase in Gr-1^dim CD11b+ cells

Genotype
MGI:5447946

ht2

• Allelic Composition: Nras^tm1.1Emfu/Nras⁺
• Genetic Background: involves: 129S1/Sv * FVB/N

growth/size/body

decreased body weight ( J:189834 )

• transient reduction in body weight in some mice, which is compensated before adulthood