All Phenotypes Ptch1<tm1.1Hahn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptch1^tm1.1Hahn
targeted mutation 1.1, Heidi Hahn
MGI:5447563

Summary

2 genotypes

Allelic Composition	Ptch1^tm1.1Hahn/Ptch1^tm1.1Hahn
Genetic Background	involves: 129 * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1^tm1.1Hahn mutation (0 available); any Ptch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice died before or around E9.5

nervous system

open neural tube ( J:149148 )

• severe neural tube closure defects

embryo

open neural tube ( J:149148 )

• severe neural tube closure defects

Allelic Composition	Ptch1^tm1.1Hahn/Ptch1⁺
Genetic Background	involves: 129 * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1^tm1.1Hahn mutation (0 available); any Ptch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:149148 )

• median survival is 148 days

neoplasm

increased tumor incidence ( J:149148 )

• hamartomatous gastrointestinal cystic tumors in 9 of 110 mice located in wall of the stomach, of the intestine or located within pancreatic ducts

• in 23 of 110 mice

• in 9 of 110 mice

nervous system

• in 9 of 110 mice

muscle

• in 23 of 110 mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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