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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(Pyy)Paba
targeted mutation 1, Paul A Baldock
MGI:5447471
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba involves: 129S4/SvJae MGI:5447473


Genotype
MGI:5447473
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(Pyy)Paba
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Gt(ROSA)26Sortm1(Pyy)Paba mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lower bone mass and reduced bone size in Gt(ROSA)26Sortm1(Pyy)Paba/Gt(ROSA)26Sortm1(cre/ERT2)Tyj females

growth/size/body
decreased lean body mass ( J:189512 )
• in females prior to tamoxifen treatment

skeleton
short femur ( J:189512 )
• in females after tamoxifen treatment
small vertebrae ( J:189512 )
• decrease in vertebral height in females after tamoxifen treatment
abnormal osteoclast morphology ( J:189512 )
• increase in osteoclast surface in the femoral metaphysis in tamoxifen treated males and females
increased osteoclast cell number ( J:189512 )
• in tamoxifen treated females
decreased bone mineral density of femur ( J:189512 )
• decreased bone mineral density in the femur of females after tamoxifen treatment
decreased trabecular bone volume ( J:189512 )
• in the distal femora and lumbar vertebrae in tamoxifen treated females
decreased compact bone area ( J:189512 )
• in tamoxifen treated females
abnormal bone mineralization ( J:189512 )
• decrease in the mineral apposition rate in the distal femoral metaphysis of tamoxifen treated males and females
• cancellous bone formation rate and mid-femoral endocortical MAR are decreased in tamoxifen treated females
decreased bone strength ( J:189512 )
• reduced mean polar moment of inertia in tamoxifen treated females

hematopoietic system
abnormal osteoclast morphology ( J:189512 )
• increase in osteoclast surface in the femoral metaphysis in tamoxifen treated males and females
increased osteoclast cell number ( J:189512 )
• in tamoxifen treated females

immune system
abnormal osteoclast morphology ( J:189512 )
• increase in osteoclast surface in the femoral metaphysis in tamoxifen treated males and females
increased osteoclast cell number ( J:189512 )
• in tamoxifen treated females

limbs/digits/tail
short femur ( J:189512 )
• in females after tamoxifen treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory