Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• mice die prematurely at 4-6 months of age
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behavior/neurological
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• severe seizures and convulsions
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nervous system
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• severe seizures and convulsions
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• astrocytosis of the spinal cord
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• dysmyelination of the spinal cord
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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nervous system
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• the optic tract shows some demyelination and contains numerous active microglia/macrophages
• in the chiasmal end of the optic tract, some axons show disruption of the cytoskeleton and/or accumulations of membranous organelles
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• P60 mice exhibit thinner myelin sheaths
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• proximal optic nerve shows numerous naked axons that appear normal with interspersed astrocytic processes
• the distal (chiasmal) end of the optic nerve is largely demyelinated and contains numerous active microglia/macrophages
• in the chiasmal end of the optic nerve, some axons show disruption of the cytoskeleton and/or accumulations of membranous organelles
• in the more distal portions of the P120 optic nerves, the numbers of CD45+ cells per optic nerve section are elevated more than 10-fold, however the completely demyelinated retinal portion shows no significant increase
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• the optic nerve shows a rostral to caudal progression of active demyelination with microglial/macrophage activation and chronic hypomyelination due to dys- and demyelination with low-grade inflammation
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• moderate dysmyelination
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• the duration of the stimulus-evoked compound action potentials is longer in the optic nerve, indicating a decrease in conduction velocity
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• mice exhibit impaired retrograde axonal transport in the optic nerve at sites associated with local inflammation and damaged myelin
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vision/eye
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• proximal optic nerve shows numerous naked axons that appear normal with interspersed astrocytic processes
• the distal (chiasmal) end of the optic nerve is largely demyelinated and contains numerous active microglia/macrophages
• in the chiasmal end of the optic nerve, some axons show disruption of the cytoskeleton and/or accumulations of membranous organelles
• in the more distal portions of the P120 optic nerves, the numbers of CD45+ cells per optic nerve section are elevated more than 10-fold, however the completely demyelinated retinal portion shows no significant increase
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cellular
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• in the chiasmal end of the optic tract, some axons show disruption of the cytoskeleton and/or accumulations of membranous organelles
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• mice die at around 6 months of age
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nervous system
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• astrocytosis of the spinal cord
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• dysmyelination of the spinal cord
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