Phenotypes associated with this allele

• Allele Symbol: Mdm2^tm2.1Snj
• Allele Name: targeted mutation 2.1, Steven N Jones
• Allele ID: MGI:5446921
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm2^tm2.1Snj/Mdm2^tm2.1Snj	involves: 129S4/SvJae * C57BL/6	MGI:5446928

Genotype
MGI:5446928

hm1

• Allelic Composition: Mdm2^tm2.1Snj/Mdm2^tm2.1Snj
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased mortality induced by ionizing radiation ( J:189297 )

• irradiated mice are radioresistant

neoplasm

increased tumor incidence ( J:189297 )

• in 20 of 31 mice in 24 months

increased T cell derived lymphoma incidence ( J:189297 )

• most tumors

increased B cell derived lymphoma incidence ( J:189297 )

• 1 tumor

cellular

abnormal cell cycle ( J:189297 )

• irradiated mouse embryonic fibroblasts exhibit compromised ability to undergo growth arrest after DNA damage compared with wild-type mice

decreased apoptosis ( J:189297 )

• in the tissues (small intestine, spleen and thymus) of irradiated mice

decreased thymocyte apoptosis ( J:189297 )

• from irradiated mice

immune system

decreased thymocyte apoptosis ( J:189297 )

• from irradiated mice

increased T cell derived lymphoma incidence ( J:189297 )

• most tumors

enlarged spleen ( J:189297 )

• severe

liver/biliary system

abnormal liver morphology ( J:189297 )

• cellular infiltration

renal/urinary system

abnormal kidney morphology ( J:189297 )

• cellular infiltration

hematopoietic system

decreased thymocyte apoptosis ( J:189297 )

• from irradiated mice

increased T cell derived lymphoma incidence ( J:189297 )

• most tumors

enlarged spleen ( J:189297 )

• severe

homeostasis/metabolism

decreased mortality induced by ionizing radiation ( J:189297 )

• irradiated mice are radioresistant

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:189297 )

• from irradiated mice

increased T cell derived lymphoma incidence ( J:189297 )

• most tumors

growth/size/body

enlarged spleen ( J:189297 )

• severe