Analysis Tools
mortality/aging
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• no viable pups are obtained from breeding heterozygotes
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Allele Symbol Allele Name Allele ID |
Pank2tm1.1Suja targeted mutation 1.1, Suzanne Jackowski MGI:5446719 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no viable pups are obtained from breeding heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Small size of Pank1tm1.1Suja/Pank1tm1.1Suja Pank2tm1.1Suja/Pank2tm1.1Suja mice
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• mice die within 18 days of birth
• not rescued by glucose injection
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• after P7
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• after P7
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• after P7
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• at P10
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• at P10
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• mice drag hind limbs for extended periods between the first and second weeks of birth
• however, this phenotype is resolved before the onset of morbidity leading to death
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• mice drag hind limbs for extended periods between the first and second weeks of birth
• however, this phenotype is resolved before the onset of morbidity leading to death
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• reduced Co-A-dependent fatty acid oxidation in the liver
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• by P10
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• at P10 and P14 due to reduced ketone utilization
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• mice exhibit altered fatty acid profile in the liver (reduced palmitoleic acid, oleic acid, alpha-linoleic acid and increased stearic acid) compared with wild-type mice
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• at P10
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• at P10
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• mice drag hind limbs for extended periods between the first and second weeks of birth
• however, this phenotype is resolved before the onset of morbidity leading to death
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• at P10
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• at P10
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• reduced Co-A-dependent fatty acid oxidation in the liver
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• at P10
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• at P10
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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