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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacna1ctm1Ggm
targeted mutation 1, Geoffrey G Murphy
MGI:5446616
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cacna1ctm1Ggm/Cacna1ctm1Ggm
Tg(Camk2a-cre)1557Sva/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB MGI:5446617
cn2
 		Cacna1ctm1Ggm/Cacna1ctm1Ggm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5446618


Genotype
MGI:5446617
cn1
Allelic
Composition		 Cacna1ctm1Ggm/Cacna1ctm1Ggm
Tg(Camk2a-cre)1557Sva/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1ctm1Ggm mutation (0 available); any Cacna1c mutation (141 available)
Tg(Camk2a-cre)1557Sva mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal long-term spatial reference memory ( J:189578 )
• at 30 days after the last training session (remote memory probe) mice spend less time in the training quadrant in a hidden platform Morris water maze assay
• behavior during training is similar to wild-type controls




Genotype
MGI:5446618
cn2
Allelic
Composition		 Cacna1ctm1Ggm/Cacna1ctm1Ggm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Cacna1ctm1Ggm mutation (0 available); any Cacna1c mutation (141 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:189406 )
• average survival time of 11.9 +/- 3 days following tamoxifen treatment for 5 days

cardiovascular system
dilated heart ventricle ( J:189406 )
• increase in ventricular end diastolic volume after tamoxifen treatment
decreased cardiac muscle contractility ( J:189406 )
• profound decrease in myocardial contractility, as assessed by fractional shortening, after tamoxifen treatment

muscle
decreased cardiac muscle contractility ( J:189406 )
• profound decrease in myocardial contractility, as assessed by fractional shortening, after tamoxifen treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory