Phenotypes associated with this allele

• Allele Symbol: Zfhx3^tm1.2Jtd
• Allele Name: targeted mutation 1.2, Jin-Tang Dong
• Allele ID: MGI:5446506
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfhx3^tm1.2Jtd/Zfhx3^tm1.2Jtd	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:5446524
ht2	Zfhx3^tm1.2Jtd/Zfhx3^+	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:5446523

Genotype
MGI:5446524

hm1

• Allelic Composition: Zfhx3^tm1.2Jtd/Zfhx3^tm1.2Jtd
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:189563 )

• no mice are produced from breeding heterozygotes

Genotype
MGI:5446523

ht2

• Allelic Composition: Zfhx3^tm1.2Jtd/Zfhx3⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Reduced body size of Zfhx3^tm1.2Jtd/Zfhx3⁺ mice

mortality/aging

premature death ( J:189563 )

• 20 of 70 mice die within 4 weeks of birth

postnatal lethality, incomplete penetrance ( J:189563 )

• 29 of 70 mice die within the first 48 hours after birth

• 20 of 70 mice die within 4 weeks of birth

reproductive system

abnormal fertility/fecundity ( J:189563 )

• mice exhibit prolonged conception time with only 2 pregnancies observed

growth/size/body

decreased body size ( J:189563 )

• at P10

decreased body weight ( J:189563 )

• at P10

behavior/neurological

abnormal eating behavior ( J:189563 )

• despite normal milk suckling, small mice require extended weaning

decreased locomotor activity ( J:189563 )