Phenotypes associated with this allele

• Allele Symbol: Cd22^{tm1.1(CD22)Lnit}
• Allele Name: targeted mutation 1.1, Lars Nitschke
• Allele ID: MGI:5446371
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd22^tm1.1(CD22)Lnit/Cd22^tm1.1(CD22)Lnit	involves: 129S4/SvJae	MGI:5446377

Genotype
MGI:5446377

hm1

• Allelic Composition: Cd22^{tm1.1(CD22)Lnit}/Cd22^{tm1.1(CD22)Lnit}
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:189017 )

N • mice exhibit normal numbers of follicular and mature B cell

N • mice exhibit normal serum antibody levels and mount normal antibody responses

decreased B cell number ( J:189017 )

• of recirculating B cells in the bone marrow

decreased transitional stage T1 B cell number ( J:189017 )

decreased transitional stage T2 B cell number ( J:189017 )

decreased marginal zone B cell number ( J:189017 )

abnormal B cell physiology ( J:189017 )

• injection experiments suggest that homing/migration or survival of mature B cells is impaired

• BCR stimulated B cells exhibit increased calcium signaling compared with wild-type cells

• B cell endocytosis is normal

hematopoietic system

decreased B cell number ( J:189017 )

• of recirculating B cells in the bone marrow

decreased transitional stage T1 B cell number ( J:189017 )

decreased transitional stage T2 B cell number ( J:189017 )

decreased marginal zone B cell number ( J:189017 )

abnormal B cell physiology ( J:189017 )

• injection experiments suggest that homing/migration or survival of mature B cells is impaired

• BCR stimulated B cells exhibit increased calcium signaling compared with wild-type cells

• B cell endocytosis is normal