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Allele Symbol Allele Name Allele ID |
Klbtm1.1Sakl targeted mutation 1.1, Steven A Kliewer MGI:5446140 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice fed standard chow or a high fat diet exhibit normal body weight and composition
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| N |
• mice treated with FGF21 exhibit the same disruptions in metabolism observed in FGF-treated control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in glucose infusion rate and whole-body and brown adipose tissue glucose uptake or reduction in endogenous glucose production observed in FGF-treated control mice
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• mice fed standard chow or a high fat diet and treated with FGF21 exhibit improved insulin sensitivity compared with control mice
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• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in brown adipose tissue glucose uptake observed in FGF-treated control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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