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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tpcn2tm1.1Dren
targeted mutation 1.1, Dejian Ren
MGI:5446047
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tpcn1tm1.1Dren/Tpcn1tm1.1Dren
Tpcn2tm1.1Dren/Tpcn2tm1.1Dren 		Not Specified MGI:5446050


Genotype
MGI:5446050
cx1
Allelic
Composition		 Tpcn1tm1.1Dren/Tpcn1tm1.1Dren
Tpcn2tm1.1Dren/Tpcn2tm1.1Dren
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpcn1tm1.1Dren mutation (0 available); any Tpcn1 mutation (72 available)
Tpcn2tm1.1Dren mutation (0 available); any Tpcn2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:189070 )
• absence of PI(3,5)P2-activated TPC-like currents in isolated vacuoles

hematopoietic system
abnormal macrophage physiology ( J:189070 )
• absence of PI(3,5)P2-activated TPC-like currents in isolated vacuoles




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory