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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasa1tm1Wid
targeted mutation 1, Christian Widmann
MGI:5446031
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rasa1tm1Wid/Rasa1tm1Wid involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6N MGI:5446052


Genotype
MGI:5446052
hm1
Allelic
Composition		 Rasa1tm1Wid/Rasa1tm1Wid
Genetic
Background		 involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa1tm1Wid mutation (1 available); any Rasa1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cardiomyocyte apoptosis ( J:189241 )
• in mice treated with doxorubicin
increased sensitivity to induced cell death ( J:189241 )
• embryonic cells do not survive long-term trypsin digest unlike wild-type cells
• in the cardiomyocytes of mice treated with doxorubicin
increased cellular sensitivity to ultraviolet irradiation ( J:189241 )
• mice exposed to UV-B radiation exhibit increased sunburn cells in the epidermis compared with wild-type mice
increased enterocyte apoptosis ( J:189241 )
• greater in DSS-treated mice

cardiovascular system
abnormal cardiovascular system physiology ( J:189241 )
• more impaired cardiac function (reduced end-systolic elastance) in mice treated with doxorubicin
increased cardiomyocyte apoptosis ( J:189241 )
• in mice treated with doxorubicin

digestive/alimentary system
increased enterocyte apoptosis ( J:189241 )
• greater in DSS-treated mice
decreased colon length ( J:189241 )
• greater decrease of colon length in DSS-treated mice
increased susceptibility to induced colitis ( J:189241 )
• DSS-treated mice exhibit increased epithelial cell apoptosis, decreased colon length and increased clinical score compared with wild-type mice

immune system
increased susceptibility to induced colitis ( J:189241 )
• DSS-treated mice exhibit increased epithelial cell apoptosis, decreased colon length and increased clinical score compared with wild-type mice

muscle
increased cardiomyocyte apoptosis ( J:189241 )
• in mice treated with doxorubicin




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory