Analysis Tools
mortality/aging
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• homozygous embryos are recovered at lower than expected Mendelian ratios at E7.5 (18% versus 25%) and arrest prior to gastrulation
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• no homozygous embryos are recovered at E9.5
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embryo
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• embryos arrest prior to gastrulation
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• at E7.5, embryos are developmentally delayed (~E6.0 size)
• however, many phospho-histoneH3 (PH3)-positive dividing cells are present
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• no Brachyury (T)-positive cells are observed at E7.5, suggesting failure to initiate primitive streak formation
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• at E7.5, extraembryonic tissues are poorly organized
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growth/size/body
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• at E7.5, embryos are developmentally delayed (~E6.0 size)
• however, many phospho-histoneH3 (PH3)-positive dividing cells are present
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