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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc2a8tm1Khm
targeted mutation 1, Kelle H Moley
MGI:5445581
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc2a8tm1Khm/Slc2a8tm1Khm involves: 129X1/SvJ MGI:5445701
ht2
Slc2a8tm1Khm/Slc2a8+ involves: 129X1/SvJ MGI:5445702


Genotype
MGI:5445701
hm1
Allelic
Composition
Slc2a8tm1Khm/Slc2a8tm1Khm
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc2a8tm1Khm mutation (0 available); any Slc2a8 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

homeostasis/metabolism
• mice fed a high fructose diet exhibit worsened metabolic syndrome-like state compared with wild-type mice
• mice fed a high fructose diet exhibit increased serum fructose concentration compared with wild-type mice
• however, glucose uptake is normal
• in fasting mice fed a high fructose diet
• in mice fed a high fructose diet
• in mice fed a high fructose diet

cardiovascular system
• in mice fed a high fructose diet
• in mice fed a high fructose diet

digestive/alimentary system
• enhanced jejunal fructose uptake in mice fed a high fructose diet
• however, reconstitution of Slc2a8 normalizes fructose uptake

growth/size/body
• mild at 22 weeks in mice fed standard chow




Genotype
MGI:5445702
ht2
Allelic
Composition
Slc2a8tm1Khm/Slc2a8+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc2a8tm1Khm mutation (0 available); any Slc2a8 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory