All Phenotypes Nlrc5<tm1Itl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nlrc5^tm1Itl
targeted mutation 1, inGenious Targeting Laboratory
MGI:5445207

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrc5^tm1Itl/Nlrc5^tm1Itl	C57BL/6-Nlrc5^tm1Itl	MGI:5445236

Allelic Composition	Nlrc5^tm1Itl/Nlrc5^tm1Itl
Genetic Background	C57BL/6-Nlrc5^tm1Itl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc5^tm1Itl mutation (0 available); any Nlrc5 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:188857 )

N	• mice exhibit normal cytokine production in response to pathogen- associated molecular patterns (PAMPs) and viruses

• in bone marrow-derived macrophage stimulated with herpes simplex virus

decreased interleukin-6 secretion ( J:188857 )

• in bone marrow-derived macrophage stimulated with CpG

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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