Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation
(0 available);
any
Fnip1 mutation
(59 available)
|
|
|
mortality/aging
|
• median survival is 292 days
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation
(0 available);
any
Fnip1 mutation
(59 available)
|
|
|
immune system
|
• 2- to 3-fold
• accumulation of fraction C and C'
|
|
• cell intrinsic block in B cell development at the pro-B cell fractions C-C'
• not rescued by rapamycin treatment or pre-recombined B cell receptor
|
|
• severe, nearly complete absence of conventional CD19+ cells
|
|
• absence of peripheral B cells
|
renal/urinary system
N |
• mice do not develop kidney cysts or renal failure
|
cellular
hematopoietic system
|
• 2- to 3-fold
• accumulation of fraction C and C'
|
|
• cell intrinsic block in B cell development at the pro-B cell fractions C-C'
• not rescued by rapamycin treatment or pre-recombined B cell receptor
|
|
• severe, nearly complete absence of conventional CD19+ cells
|
|
• absence of peripheral B cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation
(0 available);
any
Fnip1 mutation
(59 available)
Ightm2Cgn mutation
(1 available);
any
Igh mutation
(43 available)
|
|
|
hematopoietic system
|
• absence of peripheral B cells
|
immune system
|
• absence of peripheral B cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation
(0 available);
any
Fnip1 mutation
(59 available)
Fnip2tm1.2Lss mutation
(0 available);
any
Fnip2 mutation
(60 available)
|
|
|
neoplasm
|
• develop kidney cancer
• develop a variety of lesions with hybrid oncocytic tumors being most common
|
renal/urinary system
|
• develop kidney cancer
• develop a variety of lesions with hybrid oncocytic tumors being most common
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation
(0 available);
any
Fnip1 mutation
(59 available)
Tg(IghelMD4)4Ccg mutation
(3 available)
|
|
|
hematopoietic system
|
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
|
|
• absence of peripheral B cells
|
immune system
|
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
|
|
• absence of peripheral B cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation
(0 available);
any
Fnip1 mutation
(59 available)
Tg(BCL2)22Wehi mutation
(2 available)
|
|
|
hematopoietic system
|
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
|
immune system
|
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
|