About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fnip1tm1.2Baba
targeted mutation 1.2, Masaya Baba
MGI:5445116
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba involves: C57BL/6 MGI:5897121
hm2
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba involves: C57BL/6 * C57BL/6J * FVB/N * SJL MGI:5445162
cx3
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba
Ightm2Cgn/Ightm2Cgn 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:5445167
cx4
 		Fnip1tm1.2Baba/Fnip1+
Fnip2tm1.2Lss/Fnip2tm1.2Lss 		involves: C57BL/6 MGI:5897118
cx5
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba
Tg(IghelMD4)4Ccg/0 		involves: C57BL/6 * C57BL/6J * FVB/N * SJL MGI:5445165
cx6
 		Fnip1tm1.2Baba/Fnip1tm1.2Baba
Tg(BCL2)22Wehi/0 		involves: C57BL/6 * FVB/N * SJL MGI:5445170


Genotype
MGI:5897121
hm1
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:220672 )
• median survival is 292 days




Genotype
MGI:5445162
hm2
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Genetic
Background		 involves: C57BL/6 * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased pro-B cell number ( J:189078 )
• 2- to 3-fold
• accumulation of fraction C and C'
arrested B cell differentiation ( J:189078 )
• cell intrinsic block in B cell development at the pro-B cell fractions C-C'
• not rescued by rapamycin treatment or pre-recombined B cell receptor
decreased B cell number ( J:189078 )
• severe, nearly complete absence of conventional CD19+ cells
absent B cells ( J:189078 )
• absence of peripheral B cells

renal/urinary system
renal/urinary system phenotype ( J:189078 )
N
• mice do not develop kidney cysts or renal failure

cellular

hematopoietic system
increased pro-B cell number ( J:189078 )
• 2- to 3-fold
• accumulation of fraction C and C'
arrested B cell differentiation ( J:189078 )
• cell intrinsic block in B cell development at the pro-B cell fractions C-C'
• not rescued by rapamycin treatment or pre-recombined B cell receptor
decreased B cell number ( J:189078 )
• severe, nearly complete absence of conventional CD19+ cells
absent B cells ( J:189078 )
• absence of peripheral B cells




Genotype
MGI:5445167
cx3
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Ightm2Cgn/Ightm2Cgn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (62 available)
Ightm2Cgn mutation (1 available); any Igh mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent B cells ( J:189078 )
• absence of peripheral B cells

immune system
absent B cells ( J:189078 )
• absence of peripheral B cells




Genotype
MGI:5897118
cx4
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1+
Fnip2tm1.2Lss/Fnip2tm1.2Lss
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (62 available)
Fnip2tm1.2Lss mutation (0 available); any Fnip2 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased kidney tumor incidence ( J:220672 )
• develop kidney cancer
• develop a variety of lesions with hybrid oncocytic tumors being most common

renal/urinary system
increased kidney tumor incidence ( J:220672 )
• develop kidney cancer
• develop a variety of lesions with hybrid oncocytic tumors being most common

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Birt-Hogg-Dube syndrome DOID:0050676 OMIM:135150
 J:220672




Genotype
MGI:5445165
cx5
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (62 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased immature B cell number ( J:189078 )
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
absent B cells ( J:189078 )
• absence of peripheral B cells

immune system
increased immature B cell number ( J:189078 )
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes
absent B cells ( J:189078 )
• absence of peripheral B cells




Genotype
MGI:5445170
cx6
Allelic
Composition		 Fnip1tm1.2Baba/Fnip1tm1.2Baba
Tg(BCL2)22Wehi/0
Genetic
Background		 involves: C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1tm1.2Baba mutation (0 available); any Fnip1 mutation (62 available)
Tg(BCL2)22Wehi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell number ( J:189078 )
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes

immune system
increased B cell number ( J:189078 )
• in the bone marrow compared with Fnip1tm1.2Tes or Fnip1Gt(RRM154)Byg homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory