Phenotypes associated with this allele

• Allele Symbol: Tgs1^tm1.2Jkr
• Allele Name: targeted mutation 1.2, Janardan K Reddy
• Allele ID: MGI:5444606
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgs1^tm1.2Jkr/Tgs1^tm1.2Jkr	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N	MGI:5444608

Genotype
MGI:5444608

hm1

• Allelic Composition: Tgs1^tm1.2Jkr/Tgs1^tm1.2Jkr
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:189008 )

• die between E5.5 and E6.5

embryo

failure of blastocyst to hatch from the zona pellucida ( J:189008 )

• most blastocysts in culture do not normally hatch from the zona pellucida

embryonic growth arrest ( J:189008 )

• by E5.5

decreased embryo size ( J:189008 )

• blastocysts are smaller at E3.5

• at E5.5

abnormal blastocyst morphology ( J:189008 )

• smaller at E3.5

• appear condensed after 24 and 48 hours in culture

abnormal inner cell mass morphology ( J:189008 )

• after 4 days in culture no expansion of the ICM is seen

abnormal embryonic tissue physiology ( J:189008 )

• at E3.5 increased apoptosis and reduced proliferation are seen in blastocysts

• pyknotic nuclei and apoptotic changes are seen in the embryos at E5.5

growth/size/body

decreased embryo size ( J:189008 )

• blastocysts are smaller at E3.5

• at E5.5