Phenotypes associated with this allele

• Allele Symbol: Gdf2^tm1Sjl
• Allele Name: targeted mutation 1, Se-Jin Lee
• Allele ID: MGI:5444242
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf2^tm1Sjl/Gdf2^tm1Sjl	B6.129-Gdf2^tm1Sjl	MGI:5444248

Genotype
MGI:5444248

hm1

• Allelic Composition: Gdf2^tm1Sjl/Gdf2^tm1Sjl
• Genetic Background: B6.129-Gdf2^tm1Sjl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:189049 )

• mice treated with anti-BMP10 antibodies exhibit increased vascular density, hyperfused and larger diameter capillaries with several layers and decreased vascular radial expansion compared with wild-type mice

• however, untreated mice exhibit normal retinal vasculature

arteriovenous malformation ( J:189049 )

skeleton

abnormal skeleton morphology ( J:189049 )

vision/eye

abnormal retina vasculature morphology ( J:189049 )

• mice treated with anti-BMP10 antibodies exhibit increased vascular density, hyperfused and larger diameter capillaries with several layers and decreased vascular radial expansion compared with wild-type mice

• however, untreated mice exhibit normal retinal vasculature