Phenotypes associated with this allele

• Allele Symbol: Myc^tm1.1Itl
• Allele Name: targeted mutation 1.1, inGenious Targeting Laboratory
• Allele ID: MGI:5444112
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myc^tm1.1Itl/Myc^tm1.1Itl	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5444124

Genotype
MGI:5444124

hm1

• Allelic Composition: Myc^tm1.1Itl/Myc^tm1.1Itl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestine morphology ( J:188927 )

• aged mice exhibit intestinal hyperplasia in the small intestine and colon

abnormal intestinal goblet cell morphology ( J:188927 )

• decreased numbers of goblet cells in the small and large intestine

abnormal intestinal enteroendocrine cell morphology ( J:188927 )

• decreased numbers in the small and large intestine

abnormal large intestine crypts of Lieberkuhn morphology ( J:188927 )

• decreased in crypt depths

abnormal small intestine crypts of Lieberkuhn morphology ( J:188927 )

• increased in crypt depths

decreased Paneth cell number ( J:188927 )

• decreased numbers of Paneth cells in the small intestine

decreased small intestinal villus size ( J:188927 )

• decreased in crypt depths

abnormal enterocyte physiology ( J:188927 )

• increased migration of proliferating cells

• however, apoptosis rates are normal

abnormal enterocyte proliferation ( J:188927 )

• increased cell proliferation in the small and large intestine

homeostasis/metabolism

abnormal response to injury ( J:188927 )

• DSS-treated mice exhibit a more rapid recovery of colon length after removal of DSS compared with wild-type mice

• however, mice exhibit normal DSS-induced colitis

cellular

abnormal intestinal goblet cell morphology ( J:188927 )

• decreased numbers of goblet cells in the small and large intestine

abnormal enterocyte proliferation ( J:188927 )

• increased cell proliferation in the small and large intestine

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:188927 )

• decreased in crypt depths

abnormal small intestine crypts of Lieberkuhn morphology ( J:188927 )

• increased in crypt depths

decreased Paneth cell number ( J:188927 )

• decreased numbers of Paneth cells in the small intestine