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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cldn10tm1.1Dmu
targeted mutation 1.1, Dominik Muller
MGI:5444004
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cldn10tm1.1Dmu/Cldn10tm1.1Dmu
Tg(Cdh16-cre)91Igr/0
involves: C57BL/6 * ICR * SJL MGI:5444005


Genotype
MGI:5444005
cn1
Allelic
Composition
Cldn10tm1.1Dmu/Cldn10tm1.1Dmu
Tg(Cdh16-cre)91Igr/0
Genetic
Background
involves: C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cldn10tm1.1Dmu mutation (0 available); any Cldn10 mutation (22 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Nephrocalcinosis in Cldn10tm1.1Dmu/Cldn10tm1.1Dmu Tg(Cdh16-cre)91Igr/0 kidneys

renal/urinary system
• increase in K+ fractional excretion
• slight decrease in fractional excretion of Ca2+
• however, serum calcium levels are not increased
• fractional excretion of Mg2+ is only 52% of controls
• parallels increased urine volume
• 1.4 fold lower fractional excretion of urea
• extensive medullary calcium deposits at 10 weeks of age along the outer stripe of the outer medulla and in the inner stripe of the outer medulla at the transition to the inner medulla
• in freshly isolated tubule thick ascending limbs the permeability sequence for different cations are altered from monovalent to divalent
• increase in Mg2+ reabsorbtion
• moderate

behavior/neurological
• moderate

homeostasis/metabolism
• 1.4 fold higher serum urea concentration
• increase in K+ fractional excretion
• slight decrease in fractional excretion of Ca2+
• however, serum calcium levels are not increased
• fractional excretion of Mg2+ is only 52% of controls
• parallels increased urine volume
• 1.4 fold lower fractional excretion of urea





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory