Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo3tm1.2Jcob mutation
(0 available);
any
Rspo3 mutation
(14 available)
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Developmental arrest and vascular defects in Rspo3tm1.2Jcob/Rspo3tm1.2Jcob embryos
mortality/aging
embryo
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• development does not progress beyond early E10
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cardiovascular system
growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo3tm1.1Jcob mutation
(1 available);
any
Rspo3 mutation
(14 available)
Rspo3tm1.2Jcob mutation
(0 available);
any
Rspo3 mutation
(14 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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Rspo2ftls/Rspo2ftls Rspo3tm1.1Jcob/Rspo3tm1.2Jcob Tg(Prrx1-cre)1Cjt/0 double mutants have more severe limb defects than single mutants
limbs/digits/tail
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• slight in newborns
• however, adult mice exhibit normal limb length
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rspo2ftls mutation
(0 available);
any
Rspo2 mutation
(19 available)
Rspo3tm1.1Jcob mutation
(1 available);
any
Rspo3 mutation
(14 available)
Rspo3tm1.2Jcob mutation
(0 available);
any
Rspo3 mutation
(14 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
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Rspo2ftls/Rspo2ftls Rspo3tm1.1Jcob/Rspo3tm1.2Jcob Tg(Prrx1-cre)1Cjt/0 double mutants have more severe limb defects than single mutants
mortality/aging
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• mice die at birth as do Rspo2ftls homozygotes
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limbs/digits/tail
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• in digits of the forelimbs in 5 of 6 mice; all mice lack 1 digit
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• three shortened middle digits
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• more subtle than in hindlimbs
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• at birth, mice lack most of their hindlimbs
• hindlimb abnormalities are more severe more proximally than in Rspo2ftls homozygotes
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• severely shortened and bent in two mice
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• severely shortened in two mice
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respiratory system
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• as in Rspo2ftls homozygotes
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behavior/neurological
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• as in Rspo2ftls homozygotes
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skeleton
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• severely shortened and bent in two mice
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• severely shortened in two mice
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