Phenotypes associated with this allele

• Allele Symbol: Tcap^tm1Rnk
• Allele Name: targeted mutation 1, Ralph Knoll
• Allele ID: MGI:5443850
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcap^tm1Rnk/Tcap^tm1Rnk	Not Specified	MGI:5443876
cx2	Tcap^tm1Rnk/Tcap^tm1Rnk Tg(Myh6-Trp53*R193P)3Ljf/0	Not Specified	MGI:5443878

Genotype
MGI:5443876

hm1

• Allelic Composition: Tcap^tm1Rnk/Tcap^tm1Rnk
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:188832 )

N • under normal conditions, mice exhibit no abnormal cardiac phenotype

cardiac hypertrophy ( J:188832 )

• increased after transverse aortic constriction

cardiac fibrosis ( J:188832 )

• increased after transverse aortic constriction

increased cardiomyocyte apoptosis ( J:188832 )

• after transverse aortic constriction

increased response of heart to induced stress ( J:188832 )

• after transverse aortic constriction, mice exhibit increased cardiac hypertrophy, fibrosis and apoptosis and severe heart failure compared with wild-type mice

congestive heart failure ( J:188832 )

• severe after transverse aortic constriction

cellular

increased cardiomyocyte apoptosis ( J:188832 )

• after transverse aortic constriction

homeostasis/metabolism

increased response of heart to induced stress ( J:188832 )

• after transverse aortic constriction, mice exhibit increased cardiac hypertrophy, fibrosis and apoptosis and severe heart failure compared with wild-type mice

muscle

increased cardiomyocyte apoptosis ( J:188832 )

• after transverse aortic constriction

abnormal sarcomere morphology ( J:188832 )

• after removal of actin from cardiac sarcomeres, titin N-terminal anchorage is compromised

• however, Z-disks are normal

growth/size/body

cardiac hypertrophy ( J:188832 )

• increased after transverse aortic constriction

Genotype
MGI:5443878

cx2

• Allelic Composition: Tcap^tm1Rnk/Tcap^tm1Rnk; Tg(Myh6-Trp53*R193P)3Ljf/0
• Genetic Background: Not Specified

cardiovascular system

cardiovascular system phenotype ( J:188832 )

N • under normal conditions or following transverse aortic constriction, mice exhibit no abnormal cardiac phenotype and a rescue of the increased cardiomyocyte apoptosis observed in Tcap^tm1Rnk homozygotes