Phenotypes associated with this allele

• Allele Symbol: Hnrnpl^tm1.1Tmo
• Allele Name: targeted mutation 1.1, Tarik Moroy
• Allele ID: MGI:5442362
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hnrnpl^tm1.1Tmo/Hnrnpl^tm1.1Tmo Tg(Lck-cre)548Jxm/0	B6.Cg-Hnrnpl^tm1.1Tmo Tg(Lck-cre)548Jxm	MGI:5442376
cn2	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Hnrnpl^tm1.1Tmo/Hnrnpl^tm1.1Tmo Tg(Lck-cre)548Jxm/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:5442377

Genotype
MGI:5442376

cn1

• Allelic Composition: Hnrnpl^tm1.1Tmo/Hnrnpl^tm1.1Tmo; Tg(Lck-cre)548Jxm/0
• Genetic Background: B6.Cg-Hnrnpl^tm1.1Tmo Tg(Lck-cre)548Jxm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:188749 )

• in DN4 and CD4SP cells following the TCR beta selection checkpoint

thymus hypoplasia ( J:188749 )

• 75% reduction, cell-autonomous

abnormal T cell differentiation ( J:188749 )

• thymocyte chemotaxis is impaired

increased double-negative T cell number ( J:188749 )

• slight

decreased double-positive T cell number ( J:188749 )

decreased T cell number ( J:188749 )

• reduction is specific to TCR alpha-beta cells

• in the periphery

• however, the number of gamma-delta cells is normal

decreased CD4-positive, alpha-beta T cell number ( J:188749 )

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:188749 )

• in the thymus

hematopoietic system

increased T cell proliferation ( J:188749 )

• in DN4 and CD4SP cells following the TCR beta selection checkpoint

thymus hypoplasia ( J:188749 )

• 75% reduction, cell-autonomous

abnormal T cell differentiation ( J:188749 )

• thymocyte chemotaxis is impaired

increased double-negative T cell number ( J:188749 )

• slight

decreased T cell number ( J:188749 )

• reduction is specific to TCR alpha-beta cells

• in the periphery

• however, the number of gamma-delta cells is normal

decreased double-positive T cell number ( J:188749 )

decreased CD4-positive, alpha-beta T cell number ( J:188749 )

• in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:188749 )

• in the thymus

endocrine/exocrine glands

thymus hypoplasia ( J:188749 )

• 75% reduction, cell-autonomous

cellular

increased T cell proliferation ( J:188749 )

• in DN4 and CD4SP cells following the TCR beta selection checkpoint

Genotype
MGI:5442377

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Hnrnpl^tm1.1Tmo/Hnrnpl^tm1.1Tmo; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

immune system

abnormal T cell differentiation ( J:188749 )

• T cells either do not leave thymus or fail to migrate into the blood and to the peripheral lymphoid organs

hematopoietic system

abnormal T cell differentiation ( J:188749 )

• T cells either do not leave thymus or fail to migrate into the blood and to the peripheral lymphoid organs