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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sec63tm1.1Som
targeted mutation 1.1, Stefan Somlo
MGI:5442304
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sec63tm1.1Som/Sec63tm1.1Som involves: 129 * C57BL/6 MGI:5442318
cn2
 		Prkcshtm1Som/Prkcshtm1Som
Sec63tm1.1Som/Sec63tm1.1Som
Tg(Cdh16-cre)91Igr/0 		involves: 129 * C57BL/6 * ICR MGI:5442317


Genotype
MGI:5442318
hm1
Allelic
Composition		 Sec63tm1.1Som/Sec63tm1.1Som
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec63tm1.1Som mutation (0 available); any Sec63 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:188763 )
• no mice are present at E7.5




Genotype
MGI:5442317
cn2
Allelic
Composition		 Prkcshtm1Som/Prkcshtm1Som
Sec63tm1.1Som/Sec63tm1.1Som
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129 * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcshtm1Som mutation (0 available); any Prkcsh mutation (27 available)
Sec63tm1.1Som mutation (0 available); any Sec63 mutation (40 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver cyst ( J:188763 )
• more severe than in either single conditional knock-outs

growth/size/body
liver cyst ( J:188763 )
• more severe than in either single conditional knock-outs




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory