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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Relbtm1.1Fwei
targeted mutation 1.1, Falk Weih
MGI:5441212
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Relbtm1.1Fwei/Relbtm1.1Fwei
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:5441217
cn2
 		Relbtm1.1Fwei/Relbtm1.1Fwei
Tg(Lck-cre)I57Jxm/0 		involves: ICR MGI:5441216


Genotype
MGI:5441217
cn1
Allelic
Composition		 Relbtm1.1Fwei/Relbtm1.1Fwei
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relbtm1.1Fwei mutation (0 available); any Relb mutation (32 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:169863 )
N
• mice exhibit normal numbers of IL17-producing thymic gamma-delta T cells




Genotype
MGI:5441216
cn2
Allelic
Composition		 Relbtm1.1Fwei/Relbtm1.1Fwei
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relbtm1.1Fwei mutation (0 available); any Relb mutation (32 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal gamma-delta T cell morphology ( J:169863 )
• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

immune system
immune system phenotype ( J:169863 )
N
• alpha-beta Th17 cell differentiation is normal
abnormal gamma-delta T cell morphology ( J:169863 )
• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells
decreased interleukin-17 secretion ( J:169863 )
• in the peritoneal cavity of E. coli-infected mice
• in TCRbeta+CD4+CD44hi thymocytes
increased susceptibility to bacterial infection ( J:169863 )
• mice infected with E. coli exhibit reduced peritoneal neutrophils and IL17 in the peritoneal cavity compared with control mice




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory