Phenotypes associated with this allele

• Allele Symbol: Gjb2^{tm3.1(Gjb1)Kwi}
• Allele Name: targeted mutation 3.1, Klaus Willecke
• Allele ID: MGI:5441202
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gjb2^tm3.1(Gjb1)Kwi/Gjb2^+ Tg(Prrx1-cre)1Cjt/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J	MGI:5441208
cn2	Gjb2^tm3.1(Gjb1)Kwi/Gjb2^+ Tg(Tek-cre)1Arnd/0	involves: 129P2/OlaHsd * C57BL/6 * CBA * DBA/2 * SJL	MGI:5441206
cn3	Gjb2^tm3.1(Gjb1)Kwi/Gjb2^+ Tg(KRT5-cre)5132Jlj/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2J * SJL	MGI:5441207

Genotype
MGI:5441208

cn1

• Allelic Composition: Gjb2^{tm3.1(Gjb1)Kwi}/Gjb2⁺; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:188626 )

• mice are viable and show no obvious phenotypic abnormalities

Genotype
MGI:5441206

cn2

• Allelic Composition: Gjb2^{tm3.1(Gjb1)Kwi}/Gjb2⁺; Tg(Tek-cre)1Arnd/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * DBA/2 * SJL

normal phenotype

no abnormal phenotype detected ( J:188626 )

• mice do not exhibit any developmental abnormalities

Genotype
MGI:5441207

cn3

• Allelic Composition: Gjb2^{tm3.1(Gjb1)Kwi}/Gjb2⁺; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J * SJL

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:188626 )

• mice die between E16 and E18.5

immune system

abnormal lymphatic vessel morphology ( J:188626 )

• mice exhibit severely reduced dermal lymphatic capilliaries compared with control mice

homeostasis/metabolism

lymphedema ( J:188626 )

• severe

craniofacial

absent mandible ( J:188626 )

skeleton

absent mandible ( J:188626 )

growth/size/body

absent mandible ( J:188626 )