Phenotypes associated with this allele

• Allele Symbol: Tg(Adora2a-Chrm3*,-mCherry)AD6Blr
• Allele Name: transgene insertion AD6, Bryan L Roth
• Allele ID: MGI:5440979
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Adora2a-Chrm3*,-mCherry)AD6Blr/?	involves: C57BL/6J * SJL/J	MGI:5492110

Genotype
MGI:5492110

tg1

• Allelic Composition: Tg(Adora2a-Chrm3*,-mCherry)AD6Blr/?
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:191042 )

• clozapine-N-oxide (CNO) co-administered with amphetamine inhibits behavioral sensitization

• behavioral sensitization is similar in mutant and controls following administration of amphetamine without CNO

decreased locomotor activity ( J:191042 )

• following administration of CNO, mice exhibit decreased locomotion in an open field testing chamber

• spontaneous locomotion is decreased during active period (dark phase) after CNO treatment

nervous system

abnormal glutamate-mediated receptor currents ( J:191042 )

• CNO co-administered with amphetamine during induction of behavioral sensitization results in a long-lasting increase in the AMPAR/NMDAR receptor ratio in medium spiny neurons expressing Adora2a