All Phenotypes Elavl3<tm1.1Rbd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elavl3^tm1.1Rbd
targeted mutation 1.1, Robert B Darnell
MGI:5440933

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elavl3^tm1.1Rbd/Elavl3^tm1.1Rbd	either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)	MGI:5440962
hm2	Elavl3^tm1.1Rbd/Elavl3^tm1.1Rbd	involves: 129 * C57BL/6	MGI:5440960
hm3	Elavl3^tm1.1Rbd/Elavl3^tm1.1Rbd	involves: 129 * CD-1	MGI:5440961
ht4	Elavl3^tm1.1Rbd/Elavl3⁺	either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)	MGI:5440964
cx5	Elavl3^tm1.1Rbd/Elavl3^tm1.1Rbd Elavl4^tm1Okn/Elavl4^tm1Okn	either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)	MGI:5440963

Allelic Composition	Elavl3^tm1.1Rbd/Elavl3^tm1.1Rbd
Genetic Background	either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3^tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:188326 )

N	• tail-twitch on a hot plate is normal

impaired coordination ( J:188326 )

• in young adult mice

nonconvulsive seizures ( J:188326 )

• non-convulsive electrographic seizures

abnormal spike wave discharge ( J:188326 )

• mice exhibit severe continuous bilateral synchronous sharp cortical spike discharges

nervous system

nonconvulsive seizures ( J:188326 )

• non-convulsive electrographic seizures

abnormal spike wave discharge ( J:188326 )

• mice exhibit severe continuous bilateral synchronous sharp cortical spike discharges

abnormal brain wave pattern ( J:188326 )

• abnormal cortical hypersynchronization

Allelic Composition	Elavl3^tm1.1Rbd/Elavl3^tm1.1Rbd
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3^tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:188326 )

• Background Sensitivity: fewer than expected mice are produced from heterozygous parents unlike mice on a mixed background with CD-1

Allelic Composition	Elavl3^tm1.1Rbd/Elavl3^tm1.1Rbd
Genetic Background	involves: 129 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3^tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:188326 )

N	• Background Sensitivity: mice are produced in normal Mendelian ratios unlike on a C57BL/6 background

Allelic Composition	Elavl3^tm1.1Rbd/Elavl3⁺
Genetic Background	either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3^tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spike wave discharge ( J:188326 )

• mice exhibit continuous bilateral synchronous sharp cortical spike discharges sometimes accompanied by brief afterdischarges

nervous system

abnormal spike wave discharge ( J:188326 )

• mice exhibit continuous bilateral synchronous sharp cortical spike discharges sometimes accompanied by brief afterdischarges

abnormal brain wave pattern ( J:188326 )

• abnormal cortical hypersynchronization

Allelic Composition	Elavl3^tm1.1Rbd/Elavl3^tm1.1Rbd Elavl4^tm1Okn/Elavl4^tm1Okn
Genetic Background	either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl3^tm1.1Rbd mutation (0 available); any Elavl3 mutation (28 available)
Elavl4^tm1Okn mutation (0 available); any Elavl4 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:188326 )

• mice die several hours after birth

homeostasis/metabolism

decreased glutamic acid level ( J:188326 )

• glutamate levels are reduced in the cortical tissue

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