Phenotypes associated with this allele

• Allele Symbol: Il27^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5440910
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il27^tm1Lex/Il27^tm1Lex	involves: 129S/SvEvBrd	MGI:5440927

Genotype
MGI:5440927

hm1

• Allelic Composition: Il27^tm1Lex/Il27^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating interleukin-12b level ( J:187660 )

• in mice infected with T. gondii

immune system

increased circulating interleukin-12b level ( J:187660 )

• in mice infected with T. gondii

increased interferon-gamma secretion ( J:187660 )

• in mice infected with T. gondii

increased susceptibility to parasitic infection induced morbidity/mortality ( J:187660 )

• in mice infected with T. gondii

• however, lethality is rescued by treatment with wild-type TH1 T regulatory cells

mortality/aging

increased susceptibility to parasitic infection induced morbidity/mortality ( J:187660 )

• in mice infected with T. gondii

• however, lethality is rescued by treatment with wild-type TH1 T regulatory cells