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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il27tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:5440910
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il27tm1Lex/Il27tm1Lex involves: 129S/SvEvBrd MGI:5440927


Genotype
MGI:5440927
hm1
Allelic
Composition		 Il27tm1Lex/Il27tm1Lex
Genetic
Background		 involves: 129S/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il27tm1Lex mutation (1 available); any Il27 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating interleukin-12b level ( J:187660 )
• in mice infected with T. gondii

immune system
increased circulating interleukin-12b level ( J:187660 )
• in mice infected with T. gondii
increased interferon-gamma secretion ( J:187660 )
• in mice infected with T. gondii
increased susceptibility to parasitic infection induced morbidity/mortality ( J:187660 )
• in mice infected with T. gondii
• however, lethality is rescued by treatment with wild-type TH1 T regulatory cells

mortality/aging
increased susceptibility to parasitic infection induced morbidity/mortality ( J:187660 )
• in mice infected with T. gondii
• however, lethality is rescued by treatment with wild-type TH1 T regulatory cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory