Phenotypes associated with this allele

• Allele Symbol: Arfgef2^tm1Itl
• Allele Name: targeted mutation 1, inGenious Targeting Laboratory
• Allele ID: MGI:5440903
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arfgef2^tm1Itl/Arfgef2^tm1Itl	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5440905
ht2	Arfgef2^tm1Itl/Arfgef2^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5440904

Genotype
MGI:5440905

hm1

• Allelic Composition: Arfgef2^tm1Itl/Arfgef2^tm1Itl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:187673 )

N • mice exhibit normal cortical plate

abnormal neuronal migration ( J:187673 )

• impaired cell-autonomous neuronal motility

abnormal cerebral cortex morphology ( J:187673 )

• mice with exencephaly exhibit periventricular and subependymal heterotopia and abnormal cortical involutions

exencephaly ( J:187673 )

• in some mice by E18.5

ectopic neuron ( J:187673 )

• periventricular and subependymal heterotopia

growth/size/body

abnormal abdominal wall morphology ( J:187673 )

• midline gut closure defects

cellular

abnormal neuronal migration ( J:187673 )

• impaired cell-autonomous neuronal motility

Genotype
MGI:5440904

ht2

• Allelic Composition: Arfgef2^tm1Itl/Arfgef2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

nervous system

exencephaly ( J:187673 )

• in some mice by E18.5

growth/size/body

abnormal abdominal wall morphology ( J:187673 )

• midline gut closure defects