Analysis Tools
homeostasis/metabolism
| N |
• energy expenditure is normal
• fasting glucose at 6 months is normal
• young mice exhibit normolipidemia
|
|
• at 10 weeks and to a greater extent at 6 months
|
|
• at 8.5 months
|
|
• at 8 to 10 weeks of age that persists as mice age
|
|
• at 8 to 10 weeks of age that persists as mice age
|
adipose tissue
|
• when normalized to body weight
|
|
• when normalized to body weight
|
|
• increased in epididymal fat
|
growth/size/body
|
• likely due to increased energy intake
|
|
• beginning at 10 to 11 weeks of age and continuing as mice age
|
muscle
| N |
• despite metabolic defects, muscle fiber type is unaltered
|
|
• reduced in insulin stimulated muscle cells with cell surface accumulation of Slc2a4 (GLUT4)
|
cardiovascular system
|
• when normalized to body weight
|
cellular
|
• increased in epididymal fat
|
|
• reduced in insulin stimulated muscle cells with cell surface accumulation of Slc2a4 (GLUT4)
|
