All Phenotypes Erc2<tm1Toh> MGI Mouse

abnormal retina bipolar cell morphology ( J:187689 )

• ectopic bipolar cell dendrites are seen in the outer nuclear layer at 2 months of age or older

abnormal retina horizontal cell morphology ( J:187689 )

• send ectopic neurites into the outer nuclear layer

abnormal retina rod cell morphology ( J:187689 )

• reduced size of rod photoreceptor active zones

abnormal retina outer nuclear layer morphology ( J:187689 )

• some horizontal cells extended processes into the ONL at 3?4 weeks of age shortly after photoreceptor synapse maturation is completed in wild-type mice

• the number and extent of horizontal cell sprouts increases with age

• bipolar cell dendrites are detected in the ONL at 2 months of age or older

abnormal retina outer plexiform layer morphology ( J:187689 )

• distance between photoreceptor nuclei and horizontal/bipolar cell nuclei is reduced and reduced presynaptic profiles are seen in the OPL

thin retina outer plexiform layer ( J:187689 )

• decreased vertical extension

• significant reduction in the area occupied by presynaptic profiles

abnormal eye electrophysiology ( J:187689 )

• ganglion cells show a significantly increased contrast threshold to induce a spike compared to wild-type cells

abnormal rod electrophysiology ( J:187689 )

• reduced amplitudes of b-waves and oscillatory potentials

abnormal vision ( J:187689 )

• contrast sensitivity and visual acuity are reduced in a behavioral assay of vision using a virtual-reality optomotor system at all frequencies tested