About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Akr1a1tm1Maka
targeted mutation 1, Masato Kasuga
MGI:5439954
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Akr1a1tm1Maka/Akr1a1tm1Maka B6.Cg-Akr1a1tm1Maka MGI:5439957
ht2
 		Akr1a1tm1Maka/Akr1a1+ B6.Cg-Akr1a1tm1Maka MGI:5439958


Genotype
MGI:5439957
hm1
Allelic
Composition		 Akr1a1tm1Maka/Akr1a1tm1Maka
Genetic
Background		 B6.Cg-Akr1a1tm1Maka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akr1a1tm1Maka mutation (0 available); any Akr1a1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal vitamin C level ( J:188043 )
• in the liver, kidney and plasma of mice fed a diet deficient in ascorbic acid
• however, ascorbic acid levels are rescued by over-expression of the human cDNA
decreased kidney enzyme/coenzyme activity ( J:188043 )
• reduced DL-glyceraldehyde, glucuronolactone and glucuronate reductase activity in the kidney
• however, reductase activity is rescued by over-expression of the human cDNA
decreased liver enzyme/coenzyme activity ( J:188043 )
• reduced DL-glyceraldehyde, glucuronolactone and glucuronate reductase activity in the liver
• however, ascorbic acid levels are rescued by over-expression of the human cDNA

liver/biliary system
decreased liver enzyme/coenzyme activity ( J:188043 )
• reduced DL-glyceraldehyde, glucuronolactone and glucuronate reductase activity in the liver
• however, ascorbic acid levels are rescued by over-expression of the human cDNA

renal/urinary system
decreased kidney enzyme/coenzyme activity ( J:188043 )
• reduced DL-glyceraldehyde, glucuronolactone and glucuronate reductase activity in the kidney
• however, reductase activity is rescued by over-expression of the human cDNA




Genotype
MGI:5439958
ht2
Allelic
Composition		 Akr1a1tm1Maka/Akr1a1+
Genetic
Background		 B6.Cg-Akr1a1tm1Maka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akr1a1tm1Maka mutation (0 available); any Akr1a1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased liver enzyme/coenzyme activity ( J:188043 )
• reduced glucuronolactone and glucuronate reductase activity in the liver

homeostasis/metabolism
decreased kidney enzyme/coenzyme activity ( J:188043 )
• reduced glucuronolactone and glucuronate reductase activity in the kidney
• reduced DL-glyceraldehyde activity in the kidney
decreased liver enzyme/coenzyme activity ( J:188043 )
• reduced glucuronolactone and glucuronate reductase activity in the liver

renal/urinary system
decreased kidney enzyme/coenzyme activity ( J:188043 )
• reduced glucuronolactone and glucuronate reductase activity in the kidney
• reduced DL-glyceraldehyde activity in the kidney




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/07/2026
MGI 6.24 		The Jackson Laboratory