Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1.1Ruvi mutation
(0 available);
any
Psen1 mutation
(46 available)
|
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reproductive system
N |
• male fertility is normal
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• ovaries exhibit primordial follicles near the ovarian cortex and consist largely of ovarian stromal elements
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homeostasis/metabolism
endocrine/exocrine glands
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• ovaries exhibit primordial follicles near the ovarian cortex and consist largely of ovarian stromal elements
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1.1Ruvi mutation
(0 available);
any
Psen1 mutation
(46 available)
Tg(APP)8.9Btla mutation
(1 available)
|
|
|
nervous system
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• keratan sulfate-positive-activated microglia
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• scarce small plaques in the hippocampus of young animals becoming more prominent with age
• small and scattered plaques at 6 months in the cerebral cortex
• prominent plaques with age in the neocortex and leptomeninges
• small and moderate sized plaques in the cerebral cortex
• parenchymal amyloid deposition in the cerebellum of older mice
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• in the cerebral cortex with amyloid deposition
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• neuritic dystrophy with clusters of swollen and abnormally distorted neuritic profiles
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immune system
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• keratan sulfate-positive-activated microglia
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hematopoietic system
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• keratan sulfate-positive-activated microglia
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homeostasis/metabolism