Phenotypes associated with this allele

• Allele Symbol: Actb^{tm1.1(tetO-COP4*/EYFP)Kftnk}
• Allele Name: targeted mutation 1.1, Kenji Tanaka
• Allele ID: MGI:5439159
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Actb^tm1.1(tetO-COP4*/EYFP)Kftnk/Actb^+ Tg(Mlc1-tTA)2Rhn/0	involves: 129 * 129S4/SvJaeSor * C57BL/6 * CBA	MGI:5439338

Genotype
MGI:5439338

cx1

• Allelic Composition: Actb^{tm1.1(tetO-COP4*/EYFP)Kftnk}/Actb⁺; Tg(Mlc1-tTA)2Rhn/0
• Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal astrocyte physiology ( J:193127 )

• photostimulated astrocytes release glutamate

abnormal neuron physiology ( J:193127 )

• photostimulated astrocytes release glutamate, which is sufficient to activate AMPA receptors on neighboring Purkinje cells and to induce long-term depression of parallel fiber-to-Purkinje cell synapses through activation of metabotropic glutamate receptors

• neuronal activation by glial stimulation can lead to perturbation of cerebellar modulated motor behavior