Phenotypes associated with this allele

• Allele Symbol: Gem^tm1.1Jgun
• Allele Name: targeted mutation 1.1, Jenny E Gunton
• Allele ID: MGI:5439008
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gem^tm1.1Jgun/Gem^tm1.1Jgun	involves: BALB/c * C57BL/6	MGI:5439015
ht2	Gem^tm1.1Jgun/Gem^+	involves: BALB/c * C57BL/6	MGI:5439014

Genotype
MGI:5439015

hm1

• Allelic Composition: Gem^tm1.1Jgun/Gem^tm1.1Jgun
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:187922 )

N • mice exhibit normal pancreatic islet development

abnormal pancreatic beta cell physiology ( J:187922 )

• impaired glucose-stimulated calcium response and free calcium signaling

decreased insulin secretion ( J:187922 )

• first and second phase secretion

• in response to high glucose challenge

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:187922 )

N • mice exhibit normal insulin tolerance

decreased insulin secretion ( J:187922 )

• first and second phase secretion

• in response to high glucose challenge

impaired glucose tolerance ( J:187922 )

Genotype
MGI:5439014

ht2

• Allelic Composition: Gem^tm1.1Jgun/Gem⁺
• Genetic Background: involves: BALB/c * C57BL/6

reproductive system

transmission ratio distortion ( J:187922 )

• when heterozygous mice are bred, an elevated proportions of male homozygotes are produced with a reduced rate of heterozygous male mice