All Phenotypes Dag1<tm1.1Swin> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dag1^tm1.1Swin
targeted mutation 1.1, Steve J Winder
MGI:5438989

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dag1^tm1.1Swin/Dag1^tm1.1Swin	involves: 129S4/SvJae * C57BL/6	MGI:5438995
cx2	Dag1^tm1.1Swin/Dag1^tm1.1Swin Dmd^mdx/Dmd^mdx	involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn	MGI:5438997
cx3	Dag1^tm1.1Swin/Dag1^tm1.1Swin Dmd^mdx/Y	involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn	MGI:5438998

Allelic Composition	Dag1^tm1.1Swin/Dag1^tm1.1Swin
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1^tm1.1Swin mutation (0 available); any Dag1 mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:187750 )

• appeared normal and healthy, are born at expected Mendelian ratios and remain so up to 8 months of age

Allelic Composition	Dag1^tm1.1Swin/Dag1^tm1.1Swin Dmd^mdx/Dmd^mdx
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1^tm1.1Swin mutation (0 available); any Dag1 mutation (109 available)
Dmd^mdx mutation (30 available); any Dmd mutation (153 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating creatine kinase level ( J:187750 )

• less so than in Dmd^mdx homozygotes or hemizygotes

increased susceptibility to injury ( J:187750 )

• muscles exhibit partial protection against contraction-induced injury compared with Dmd^mdx homozygotes or hemizygotes

muscle

centrally nucleated skeletal muscle fibers ( J:187750 )

• less so than in Dmd^mdx homozygotes or hemizygotes

Allelic Composition	Dag1^tm1.1Swin/Dag1^tm1.1Swin Dmd^mdx/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating creatine kinase level ( J:187750 )

• less so than in Dmd^mdx homozygotes or hemizygotes

increased susceptibility to injury ( J:187750 )

• muscles exhibit partial protection against contraction-induced injury compared with Dmd^mdx homozygotes or hemizygotes

muscle

centrally nucleated skeletal muscle fibers ( J:187750 )

• less so than in Dmd^mdx homozygotes or hemizygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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