Phenotypes associated with this allele

• Allele Symbol: Havcr1^tm1Vlcg
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5438833
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Havcr1^tm1Vlcg/Havcr1^tm1Vlcg	B6.129-Havcr1^tm1Vlcg	MGI:5438834
hm2	Havcr1^tm1Vlcg/Havcr1^tm1Vlcg	C.129-Havcr1^tm1Vlcg	MGI:5438835

Genotype
MGI:5438834

hm1

• Allelic Composition: Havcr1^tm1Vlcg/Havcr1^tm1Vlcg
• Genetic Background: B6.129-Havcr1^tm1Vlcg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:187793 )

N • mice exhibit normal immune system development and homeostasis

increased interleukin-13 secretion ( J:187793 )

• in the bronchoalveolar lavage fluid of mice immunized with ovalbumin

• in splenocytes from ovalbumin-treated mice in an asthma model that are re-challenged with ovalbumin in vitro

• in splenocytes from mice immunized with ovalbumin emulsified in alum then restimulated in vitro with ovalbumin

increased interleukin-5 secretion ( J:187793 )

• in splenocytes from ovalbumin-treated mice in an asthma model that are re-challenged with ovalbumin in vitro

• in splenocytes from mice immunized with ovalbumin emulsified in alum then restimulated in vitro with ovalbumin

Genotype
MGI:5438835

hm2

• Allelic Composition: Havcr1^tm1Vlcg/Havcr1^tm1Vlcg
• Genetic Background: C.129-Havcr1^tm1Vlcg

immune system

immune system phenotype ( J:187793 )

N • mice exhibit normal immune system development and homeostasis

abnormal cytokine secretion ( J:187793 )

• ovalbumin-stimulated increase in cytokine production is not T-cell-intrinsic

increased interleukin-10 secretion ( J:187793 )

• in splenocytes from ovalbumin-treated mice in an asthma model that are re-challenged with ovalbumin in vitro

increased interleukin-13 secretion ( J:187793 )

• in the bronchoalveolar lavage fluid of mice immunized with ovalbumin

• in splenocytes from ovalbumin-treated mice in an asthma model that are re-challenged with ovalbumin in vitro

increased interleukin-17 secretion ( J:187793 )

• in splenocytes from ovalbumin-treated mice in an asthma model that are re-challenged with ovalbumin in vitro

• in splenocytes from mice immunized with ovalbumin emulsified in alum then restimulated in vitro with ovalbumin

increased interleukin-4 secretion ( J:187793 )

• in splenocytes from ovalbumin-treated mice in an asthma model that are re-challenged with ovalbumin in vitro

increased interleukin-5 secretion ( J:187793 )

• in splenocytes from ovalbumin-treated mice in an asthma model that are re-challenged with ovalbumin in vitro

• in splenocytes from mice immunized with ovalbumin emulsified in alum then restimulated in vitro with ovalbumin

respiratory system inflammation ( J:187793 )

• ovalbumin immunized mice exhibit an increase in eosinophil and macrophages within the airways compared with wild-type mice

• however, mucus production and goblet cell hyperplasia is the same as in wild-type mice

respiratory system

respiratory system inflammation ( J:187793 )

• ovalbumin immunized mice exhibit an increase in eosinophil and macrophages within the airways compared with wild-type mice

• however, mucus production and goblet cell hyperplasia is the same as in wild-type mice