Phenotypes associated with this allele

• Allele Symbol: Mrtfb^tm1.1Msp
• Allele Name: targeted mutation 1.1, Michael S Parmacek
• Allele ID: MGI:5438551
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrtfb^tm1.1Msp/Mrtfb^tm1.1Msp	involves: 129	MGI:5438553

Genotype
MGI:5438553

hm1

• Allelic Composition: Mrtfb^tm1.1Msp/Mrtfb^tm1.1Msp
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:187713 )

• fewer embryos than expected are found at E15.5 and none are found at E16.5

cardiovascular system

abnormal artery morphology ( J:187713 )

• striking defects in the organization of the tunica media in E12.5-E15.5 arteries

dilated third pharyngeal arch artery ( J:187713 )

• aneurysmal dilation of the 3rd pharyngeal arch artery is commonly seen by E12.5

abnormal aorta tunica media morphology ( J:187713 )

• at E12.5 thicker in some sections and reduced to a single layer in other sections

• at E15.5 the tunica media is populated with rounded heterogeneous cells lacking a predominant orientation and obvious gaps appearing between cells

abnormal descending thoracic aorta morphology ( J:187713 )

• the lumen appears eccentric with some thinning of the tunica media

dilated aorta ( J:187713 )

• dilation of the midline derivative of the ventral aorta at E11 in all embryos

aortic aneurysm ( J:187713 )

• aneurysmal dilation of the aortic arch is commonly seen by E12.5

abnormal common carotid artery morphology ( J:187713 )

• striking disruption of cell-cell and cell-matrix relationships in the tunica media in the common carotid arteries

• aneurysmal dilation, dissection and rupture are commonly seen at E13.5

• massive aneurysmal dilation of the common carotid artery displacing the trachea and esophagus is seen in surviving embryos at E15.5

• at E15.5 medial and neointimal vascular smooth muscle cells are characterized by marked heterogeneity in size and orientation

dilated basilar artery ( J:187713 )

• dilation of the basilar artery at E13.5

abnormal cardiac outflow tract development ( J:187713 )

• patterning defects are detected at E14.5-E16.5

aneurysm ( J:187713 )

• aneurysmal dilation of the 3rd pharyngeal arch artery is commonly seen by E12.5

• aneurysmal dilation and arterial rupture is also seen in other arteries supplying the head and neck

• massive aneurysmal dilation of the common carotid artery displacing the trachea and esophagus is seen in surviving embryos at E15.5

internal hemorrhage ( J:187713 )

• focal hemorrhage at E11.5 in some embryos

• by E12.5 all mice display regions of hemorrhage and at E15.5 surviving embryos display large areas of hemorrhage covering their bodies

lung hemorrhage ( J:187713 )

• intraparenchymal hemorrhage is seen at E12.5-E15.5

liver hemorrhage ( J:187713 )

• intraparenchymal hemorrhage is seen at E12.5-E15.5

cellular

abnormal cell adhesion ( J:187713 )

• es cells fail to adhere to uncoated tissue culture plates and show profound defects in adhesion to bovine serum albumin coated plates

craniofacial

dilated third pharyngeal arch artery ( J:187713 )

• aneurysmal dilation of the 3rd pharyngeal arch artery is commonly seen by E12.5

embryo

dilated third pharyngeal arch artery ( J:187713 )

• aneurysmal dilation of the 3rd pharyngeal arch artery is commonly seen by E12.5

nervous system

dilated basilar artery ( J:187713 )

• dilation of the basilar artery at E13.5

respiratory system

lung hemorrhage ( J:187713 )

• intraparenchymal hemorrhage is seen at E12.5-E15.5

liver/biliary system

liver hemorrhage ( J:187713 )

• intraparenchymal hemorrhage is seen at E12.5-E15.5