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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh2d1b1tm3Vei
targeted mutation 3, Andre Veillette
MGI:5438032
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sh2d1b1tm3Vei/Sh2d1b1tm3Vei involves: C57BL/6 MGI:5438036
cx2
 		Sh2d1atm1Vei/Sh2d1atm1Vei
Sh2d1b1tm3Vei/Sh2d1b1tm3Vei 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5438038
cx3
 		Sh2d1atm1Pls/Sh2d1atm1Pls
Sh2d1b1tm3Vei/Sh2d1b1tm3Vei 		involves: 129S6/SvEvTac * C57BL/6 MGI:5438039


Genotype
MGI:5438036
hm1
Allelic
Composition		 Sh2d1b1tm3Vei/Sh2d1b1tm3Vei
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1b1tm3Vei mutation (0 available); any Sh2d1b1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:187430 )
• decreased killing of RMA-S

hematopoietic system
abnormal NK cell physiology ( J:187430 )
• decreased killing of RMA-S




Genotype
MGI:5438038
cx2
Allelic
Composition		 Sh2d1atm1Vei/Sh2d1atm1Vei
Sh2d1b1tm3Vei/Sh2d1b1tm3Vei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Vei mutation (0 available); any Sh2d1a mutation (9 available)
Sh2d1b1tm3Vei mutation (0 available); any Sh2d1b1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:187430 )
• decreased killing of RMA-S

hematopoietic system
abnormal NK cell physiology ( J:187430 )
• decreased killing of RMA-S




Genotype
MGI:5438039
cx3
Allelic
Composition		 Sh2d1atm1Pls/Sh2d1atm1Pls
Sh2d1b1tm3Vei/Sh2d1b1tm3Vei
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Pls mutation (4 available); any Sh2d1a mutation (9 available)
Sh2d1b1tm3Vei mutation (0 available); any Sh2d1b1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:187430 )
• decreased killing of RMA-S
• reduced ability to convert 2B4 into an inhibitory receptor

hematopoietic system
abnormal NK cell physiology ( J:187430 )
• decreased killing of RMA-S
• reduced ability to convert 2B4 into an inhibitory receptor




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory