Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1.1(Ctnna3)Jvh}
• Allele Name: targeted mutation 1.1, Jolanda van Hengel
• Allele ID: MGI:5437345
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^tm1.1(Ctnna3)Jvh/Gt(ROSA)26Sor^tm1.1(Ctnna3)Jvh	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA	MGI:5437346

Genotype
MGI:5437346

hm1

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Ctnna3)Jvh}/Gt(ROSA)26Sor^{tm1.1(Ctnna3)Jvh}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:187209 )

N • mice are born in normal Mendelian ratios

embryo

decreased trophoblast giant cell number ( J:187209 )

• invading trophoblast cells

increased trophoblast giant cell number ( J:187209 )

• glycogen trophoblasts in junctional zones

abnormal placenta physiology ( J:187209 )

• mice exhibit reduced trophoblast invasion beyond the giant cell layer into the decidual layer compared with control mice

• at E16.5, mice exhibit increased spongiotrophoblast cell proliferation in the junctional zone compared with control mice