Phenotypes associated with this allele

• Allele Symbol: Ctbs^tm1Tbec
• Allele Name: targeted mutation 1, Tommaso Beccari
• Allele ID: MGI:5437306
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctbs^tm1Tbec/Ctbs^tm1Tbec	involves: 129S2/SvPas * C57BL/6N	MGI:5437310

Genotype
MGI:5437310

hm1

• Allelic Composition: Ctbs^tm1Tbec/Ctbs^tm1Tbec
• Genetic Background: involves: 129S2/SvPas * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urine homeostasis ( J:185162 )

• mice exhibit increased urine oligosaccharides (10-fold in Man3GlcNAc3 and accumulation of Man3GlcNAc2) compared wild-type mice

abnormal proximal convoluted tubule morphology ( J:185162 )

• accumulation of dark multilamellar inclusions

liver/biliary system

abnormal Kupffer cell morphology ( J:185162 )

• some mice exhibit increased size of vesiculated Kupffer cells in the liver compared with wild-type mice

cellular

abnormal cell physiology ( J:185162 )

• mice tissues exhibit accumulated oligosaccharides compared with wild-type mice

cardiovascular system

abnormal Kupffer cell morphology ( J:185162 )

• some mice exhibit increased size of vesiculated Kupffer cells in the liver compared with wild-type mice

hematopoietic system

abnormal Kupffer cell morphology ( J:185162 )

• some mice exhibit increased size of vesiculated Kupffer cells in the liver compared with wild-type mice

homeostasis/metabolism

abnormal urine homeostasis ( J:185162 )

• mice exhibit increased urine oligosaccharides (10-fold in Man3GlcNAc3 and accumulation of Man3GlcNAc2) compared wild-type mice

immune system

abnormal Kupffer cell morphology ( J:185162 )

• some mice exhibit increased size of vesiculated Kupffer cells in the liver compared with wild-type mice