About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox7tm1Dsco
targeted mutation 1, Daryl A Scott
MGI:5437220
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sox7tm1Dsco/Sox7tm1.1Dsco
Tg(Tek-cre)1Ywa/0 		involves: 129S/SvEv * C57BL/6 * SJL MGI:7543476
cn2
 		Sox7tm1Dsco/Sox7tm1Dsco
Tg(Tek-cre)1Ywa/0 		involves: 129S/SvEv * C57BL/6 * SJL MGI:7543477


Genotype
MGI:7543476
cn1
Allelic
Composition		 Sox7tm1Dsco/Sox7tm1.1Dsco
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox7tm1.1Dsco mutation (0 available); any Sox7 mutation (21 available)
Sox7tm1Dsco mutation (0 available); any Sox7 mutation (21 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:338879 )
• most embryos die prior to E15.5; two rare survivors are found at E15.5

cardiovascular system
ventricular septal defect ( J:338879 )
• one of 2 rare embryos that survived to E15.5 show a ventricular septal defect (VSD), not observed in control embryos




Genotype
MGI:7543477
cn2
Allelic
Composition		 Sox7tm1Dsco/Sox7tm1Dsco
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox7tm1Dsco mutation (0 available); any Sox7 mutation (21 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:338879 )
• most embryos died prior to E15.5; one rare survivor was found at E15.5

cardiovascular system
atrioventricular cushion hypoplasia ( J:338879 )
• at E10.5, atrioventricular (AV) endocardial cushions were hypocellular with a severe reduction in mesenchymal cell density relative to control embryos
ventricular septal defect ( J:338879 )
• single embryo that survived to E15.5 showed a ventricular septal defect (VSD)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory