Analysis Tools
mortality/aging
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• mice die during embryogenesis
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Allele Symbol Allele Name Allele ID |
Slc8a1tm1Herc targeted mutation 1, Andre Herchuelz MGI:5436242 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die during embryogenesis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 weeks due to increased proliferation
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• following removal of extracellular sodium, islet cells exhibit half as much of an increase in calcium uptake compared with wild-type cells
• glucose-stimulated islet cells exhibit altered internal calcium oscillations compared with wild-type cells
• at high glucose concentrations, islets exhibit lower glucose oxidation compared with wild-type cells
• under hypoxic conditions, islet cells exhibit reduced cell death compared with wild-type cells
• in transplantation experiments, islet cells are more efficient at curing diabetes compared with wild-type cell
• islet cells exhibit increased endoplasmic reticulum calcium stores compared with wild-type cells
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• increased cell proliferation
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• increased cell proliferation
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• stimulated islet cells exhibit higher insulin content and release compared with wild-type mice
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• at high glucose concentrations, islets exhibit lower glucose oxidation compared with wild-type cells
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• stimulated islet cells exhibit higher insulin content and release compared with wild-type mice
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• increased cell proliferation
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• increased cell proliferation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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