Phenotypes associated with this allele

• Allele Symbol: Rnls^tm1Gvd
• Allele Name: targeted mutation 1, Gary V Desir
• Allele ID: MGI:5433853
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnls^tm1Gvd/Rnls^tm1Gvd	involves: 129S1/Sv * C57BL/6	MGI:5435871

Genotype
MGI:5435871

hm1

• Allelic Composition: Rnls^tm1Gvd/Rnls^tm1Gvd
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

heart left ventricle hypertrophy ( J:186878 )

• with increased left ventricular posterior wall thickness and smaller left ventricular diameter

abnormal cardiovascular system physiology ( J:186878 )

• isolated perfused hearts treated with norepinephrine exhibit increased rate-pressure product compared with wild-type hearts

increased heart rate ( J:186878 )

• in anesthetized mice

• in active mice

increased myocardial infarct size ( J:186878 )

• 3-fold following ischemia and reperfusion

• however, perfusion with recombinant renalase rescues phenotype

increased systemic arterial blood pressure ( J:186878 )

• in anesthetized mice

• in mice treated with TOCRIS A-61603 hydrobromide

increased systemic arterial diastolic blood pressure ( J:186878 )

• during activity and at rest

increased systemic arterial systolic blood pressure ( J:186878 )

• during activity and at rest

homeostasis/metabolism

increased myocardial infarct size ( J:186878 )

• 3-fold following ischemia and reperfusion

• however, perfusion with recombinant renalase rescues phenotype

increased circulating adrenaline level ( J:186878 )

increased circulating noradrenaline level ( J:186878 )

increased dopamine level ( J:186878 )

• in the plasma

abnormal response/metabolism to endogenous compounds ( J:186878 )

• isolated perfused hearts treated with norepinephrine exhibit increased rate-pressure product compared with wild-type hearts

muscle

heart left ventricle hypertrophy ( J:186878 )

• with increased left ventricular posterior wall thickness and smaller left ventricular diameter

growth/size/body

heart left ventricle hypertrophy ( J:186878 )

• with increased left ventricular posterior wall thickness and smaller left ventricular diameter