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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpx4tm3Marc
targeted mutation 3, Marcus Conrad
MGI:5433757
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpx4tm3Marc/Gpx4tm3Marc involves: 129P2/OlaHsd MGI:5433764


Genotype
MGI:5433764
hm1
Allelic
Composition		 Gpx4tm3Marc/Gpx4tm3Marc
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4tm3Marc mutation (0 available); any Gpx4 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:186906 )
N
• female mice exhibit normal fertility
abnormal sperm mitochondrial sheath morphology ( J:186906 )
• sliding mitochondria along midpiece
• swelling of some mitochondria
abnormal sperm principal piece morphology ( J:186906 )
• extrusion of microtubules and outer dense fibers from the principal piece
kinked sperm flagellum ( J:186906 )
• bent sperm
abnormal sperm head morphology ( J:186906 )
• sperm head detached from midpiece
male infertility ( J:186906 )
• male mice are infertile in conventional breeding and in vitro fertilization assays
• however, intracytoplasmic sperm injection produces viable offspring
impaired fertilization ( J:186906 )
• no pronuclei-stage embryos are generated from in vitro fertilization assays with male sperm and wild-type oocytes
decreased fertilization frequency ( J:186906 )
• no pronuclei-stage embryos are generated from in vitro fertilization assays with male sperm and wild-type oocytes

cellular
cellular phenotype ( J:186906 )
N
• cell proliferation and proliferation is normal in cells from the testis, hippocampus, caput epididymis, cauda epididymis, kidney, heart, cerebellum, spleen and liver
abnormal sperm mitochondrial sheath morphology ( J:186906 )
• sliding mitochondria along midpiece
• swelling of some mitochondria
abnormal sperm principal piece morphology ( J:186906 )
• extrusion of microtubules and outer dense fibers from the principal piece
kinked sperm flagellum ( J:186906 )
• bent sperm
abnormal sperm head morphology ( J:186906 )
• sperm head detached from midpiece




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory